Anti-TNF strategies in paediatric Crohn's disease

摘要

As the treatment of Crohn's disease (CD) cannot be directed against a known aetiological agent, it must focus on the pathogenic mechanisms of the disease leading to chronic intestinal inflammation. Traditionally, non-specific anti-inflammatory and immunosuppressive drugs (aminosalicylates, corticosteroids, azathioprine, 6-mercaptopurine) are used to reduce the inflammatory process. Often, these drugs are not sufficiently effective and induce side-effects.