Preconditioning by Adenosine Is Associated with Increased Sarcoplasmic Reticulum Phospholamban Expression

摘要

We investigate the hypothesis that adenosine cardioprotective effect may be mediated by changes in calcium homeostasis, affecting calcium release from the SR. We found that R-PIA, an AY agonist, increased PLB gene expression without effecting SERCA2a and RyR2. IB-MECA, an A3 agonist, did not produce any change and CPX, an A1 antagonist, reverted R-PIA effects. We conclude that modulation of SR function may be involved in the anti-ischemic effect of adenosine.