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IRREVERSIBLE INHIBITOR OF SARCOPLASMIC RETICULUM Ca2+-ADENOSINE TRIPHOSPHATASE
IRREVERSIBLE INHIBITOR OF SARCOPLASMIC RETICULUM Ca2+-ADENOSINE TRIPHOSPHATASE
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机译:钙质网Ca 2 + Sup>-腺苷三磷酸酶的不可逆抑制剂
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摘要
FIELD: biochemistry, organic chemistry. SUBSTANCE: invention relates to the use of derivatives of 1,2-benzisothiazole-3-one of the general formula given in the invention where R1 means lower alkyl or phenyl and R2 is H or NO2 which are used as irreversible inhibitor of Ca2+-adenosine triphosphatase of sarcoplasmic reticulum (SERCA). Derivatives of 1,2-benzisothiaxole- -3-one of the general formula given in the invention exhibit the more expressed irreversible effect on SERCA as compared with its analog, i. e. 7-chloro-4-nitrobenz-2,1,3- oxadiazole (NBD-Cl). NBD-Cl under close conditions inhibits enzyme irreversibly also but its effect eliciting in concentration 0.75 mM is compared with effect of 6-nitro-2-phenyl-1,2- -benzisothiazole-3-one in concentration 0.15 mM. EFFECT: valuable biochemical properties of inhibitor. 1 tbl, 1 dwg
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