Purpose / Introduction Taste masking of bitter drugs is critical for the successful development of solid oral dosage forms as it correlates with patient compliance. The increasing demand for new formulations as part of drug life cycle management or to address New Chemical Entities challenges is boosting the use of spray congealing, which can be described as a combination of spray drying and hot melt extrusion techniques. This platform can match many of the systems prepared by spray drying or hot melt extrusion but also enables the preparation of powders with unique properties and applications. In this work, the potential of spray congealing for taste masking was explored and compared to another commonly used technology, hot melt extrusion.
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