A MATHEMATICAL APPROACH TO THE STUDY OF SIGNAL TRANSDUCTION PATHWAYS IN MAPK CASCADE

摘要

Mathematical modelling of signal transduction pathways is a very useful approach for understanding molecular mechanisms. Without this theoretical framework, it is, in general, difficult to understand the high complexity of metabolic phenomena. The main goal of computational biology, and in particular of systems biology, is to define a comprehensive model that can accurately represent the experimental data and, mainly, serve as a fundamental tool to generate and test hypotheses. In this work we reexamine the mathematical model of MAP kinase cascade.