Independent Component Analysis and Raman Microspectroscopy on Paraffinised Non Dewaxed Cutaneous Biopsies: A promising Methodology for Melanoma Early Diagnosis

摘要

This paper deals with a promising methodology for melanoma early diagnosis. Raman spectroscopy is used to record vibrational information of paraffinised tumoral tissues. Independent Component Analysis (ICA) is performed on Raman spectra to numerically deparaffinise spectra. Resulting deparaffinised spectra are used to extract discriminant information specific to malignant and benign tumors. These spectral specificities can be employed as molecular descriptors of the type of pathology. A comparison with Principal Component Analysis (PCA) shows that ICA is more suited to process this kind of problem.