Gemcitabine-induced apoptosis in adrug-resistant mouse leukemia L1210 cell linethat does not express p53

摘要

Gemcitabine (2',2'-difluorodeoxycytidine) is a drug that has recently been addedto the compounds used to treat human cancers. In several different studies,Gemcitabine as a single agent or in combination with other drugs, which haveknown antitumor activity in the clinical setting, has been shown to be a very usefuland promising drug in the treatment of human cancers of various types (Albertset al., 2003; Apostolidou et al., 2003; Berlin and Rothenberg, 2003; Chen et al., 2003;Karasek et al., 2003; Kralidis et al., 2003; Lehman et al., 2003; Lim et al., 2003;Tomek and Manegold, 2003). Gemcitabine appears to be well tolerated by thepatients receiving this drug.