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Morphine Pharmacokinetics Following Intra-Articular Administration of a Novel Sustained Release Opioid (CDS-PM-101) for the Relief of Post-Operative Orthopaedic Pain

机译：Muphine药代动力学后，关节内施用新型持续释放阿片类药物（CDS-PM-101），用于缓解术后整形外科疼痛

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A novel compound (CDS-PM-101) has been developed using CDS CODRUG? technology to provide extended morphine release. CDSPM- 101 has very low aqueous solubility. When formulated and administered intra-articularly, the drug dissolves slowly. Once in solution, however, it rapidly hydrolyzes to release morphine within the joint.

机译：使用CDS Rodrug开发了一种新型化合物（CDS-PM-101）？技术提供延长的吗啡释放。 CDSPM-101具有非常低的水溶性。当分节内分析和施用，药物缓慢溶解。然而，在溶液中，它迅速水解以在关节内释放吗啡。

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《Controlled Release Society annual meeting》|2004年||共2页
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中图分类生物工程学（生物技术）;
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1. Intra-synovial, compared to intra-articular morphine provides better pain relief following knee arthroscopy menisectomy: (L'administration intra-synoviale de morphine, comparee a l'administration intra-articulaire, fournit une meilleure analgesie a l [J] . Kligman M, Bruskin A, Sckliamser J, Canadian journal of anesthesia: Journal canadien d'anesthesie . 2002,第4期

机译：与关节内吗啡相比，滑膜内给药可更好地缓解膝关节镜半月板切除术后的疼痛：
2. Sustained relief of chronic pain. Pharmacokinetics of sustained release morphine. [J] . Gourlay GK Clinical pharmacokinetics . 1998,第3期

机译：持续缓解慢性疼痛。缓释吗啡的药代动力学。
3. Population pharmacokinetics of oral morphine and its glucuronides in children receiving morphine as immediate-release liquid or sustained-release tablets for cancer pain (see comments) [J] . Hunt A, Joel S, Dick G, The Journal of pediatrics . 1999,第1期

机译：接受吗啡作为癌症疼痛的速释液体或持续释放片剂的儿童中口服吗啡及其葡糖苷酸的群体药代动力学（请参阅评论）
4. Morphine Pharmacokinetics Following Intra-Articular Administration of a Novel Sustained Release Opioid (CDS-PM-101) for the Relief of Post-Operative Orthopaedic Pain [C] . Controlled Release Society annual meeting . 2004

机译：Muphine药代动力学后，关节内施用新型持续释放阿片类药物（CDS-PM-101），用于缓解术后整形外科疼痛
5. Patient attributes influencing pain intensity, opioid consumption, and comfort goal attainment in post-operative unilateral knee arthroplasty patients. [D] . Gentile, Deborah L. 2010

机译：患者的属性会影响术后单侧膝关节置换患者的疼痛强度，阿片类药物的消耗以及达到舒适目标的程度。
6. Endogenous Opioid Inhibition of Chronic Low Back Pain Influences Degree of Back Pain Relief Following Morphine Administration [O] . Stephen Bruehl, John W. Burns, Rajnish Gupta, -1

机译：吗啡给药后慢性下腰痛的内源性阿片样物质抑制影响腰痛缓解程度
7. Figure 1: Percent change in weight, relative to 2006, of opioids used to treat pain (hydrocodone = 3,064.0, oxycodone = 922.2, codeine = 822.1, morphine = 765.8, methadone = 278.2, meperidine = 235.8, hydromorphone = 46.2, fentanyl = 22.5, oxymorphone = 3.3 kg), an opioid use disorder (OUD, methadone = 249.6, buprenorphine = 12.9 kg), or all (pain + OUD) by Morphine Mg Equivalent (A) or by weight (B) in Texas as reported to the Drug Enforcement Administration. [O] . -1

机译：图1：相对于2006年的重量变化百分比用于治疗疼痛的阿片类药物（氢酮= 3,064.0，Codeine = 822.1，Meperidine = 235.8，乙基= 22.5，Fentanyl = 235.8，Fentanyl = 22.5 ，oxymorphone = 3.3 kg），一种阿片类药物使用障碍（oud，美沙酮= 249.6，buprenorphine = 12.9kg），或所有（疼痛+ oud）的吗啡mg当量（a）或德克萨斯州的重量（b）据报道药物执法管理。

Morphine Pharmacokinetics Following Intra-Articular Administration of a Novel Sustained Release Opioid (CDS-PM-101) for the Relief of Post-Operative Orthopaedic Pain

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