Clinic immunological peculiarities of pulmonary tuberculosis in biogeochemical subregions of Chuvash Republic

摘要

Revealed peculiarities of specific process course, its complications, accompanying diseases can probably be explained by biogeochemical conditions of Chuvash Republic biosphere, where patients with pulmonary tuberculosis have been. In Prisursky subregion silicon excess with iodine lack leads in population to the increase of triioditrin production with more frequent development of autonomic adenoma of thyroid gland, which leads to exudative component intensification of specific inflammation in patients with pulmonary tuberculosis. In Prisursky subregion the acute course of tuberculosis is noted. Progressing of the process is quick, exudative component of inflammation is marked. Involution of specific process in Prisursky subregion begins earlier but characterized by undulating course with exacerbation periods. Immune status of tuberculosis patients, living in Pricubninotsivilky subregion with silicon deficiency, is characterized by marked suppression of T-system immunity, which is important in immune mechanisms of mycobacterium tuberculosis elimination. In Pricubninotsivilsky subregion with the reduce of immunobiological resistance of organism the prevalence of alternative reactions of specific inflammation is noted. Tuberculosis has more severe form with small number of symptoms, has common character, it is distinguished by long duration, has steady progressing with frequent destruction of lung tissue, semination. Specific process is complicated by drug stability to antituberculosis preparations in the most part of patients.