Effect of hormone replacement therapy on the reverse cholesterol transport

摘要

Hormone replacement therapy (HRT) in healthy postmenopausal women modifies the HDL lipid composition, selectively increases the HDL subpopulation that only contains apolipoprotein A-I (LpA-I) and decreases the activity of phospholipid transfer protein (PLTP), a key piotein regulating HDL levels.In addition, HRT increases the plasma capacity to promote cholesterol efflux in vitro.These findings demonstrate that HRT not only increases HDL-cholestetol levels, but also modifies HDL physiochemical properties, possibly optimising its function in the reverse cholesterol transport.