EFFECT OF THE PHASE BEHAVIOUR OF SOLVENTANTISOLVENT SYSTEMS IN GAS-ANTISOLVENT CRYSTALLISATION

摘要

Crystallisation processes using supercritical CO_2 as an antisolvent have been shown to be feasible for medium and large scale applications in the past years. However, the development of concrete applications still requires a lot of experimental and theoretical work based on detailed experience in the field. Here we discuss some effects based on ternary phase equilibria aimed at crystallising paracetamol. A calculation method for the proper choice of the solvent is proposed, based on a global phase diagram method.