Effect of the phase behaviour of the solvent-antisolvent systems on the gas-antisolvent-crystallisation of paracetamol

摘要

The influence of the phase behaviour of the solvent-antisolvent system on the process conditions for the gas-antisolvent process is investigated.The two fluids are modelled by the Peng-Robinson equation of state while the dissolved solid is described by a Clapeyron-type approach.Based on the correlation of the ternary system,a liquid-liquid immiscibility region has been found which hinders the proper crystallisation of the solute.A thorough investigation of the binary solvent-antisolvent system by the global phase diagram methods yields a criterion for the proper choice of the solvent.The crucial property turns out to be the distance of the solvent-antisolvent system from the identical curve in the global phase diagram.