Precipitation of Lycopene by Continuous Supercritical Antisolvent Process

摘要

The re-crystallization of Lycopene from dichloromethane solutions has been studied in a continuously operating antisolvent apparatus. Influence parameters like pressure, temperature, solute concentration in the feed solution, solution to CO_2 flow ratios and mixing nozzle were tested. Successful re-crystallization of Lycopene resulted in particle sizes smaller than 1 micron achieved at 90 bar, independent from the other operation conditions. Temperature was limited with 45°C because of degradation of Lycopene at higher values.