Rhodium-Catalyzed Asymmetric Addition of Organozinc Reagents

摘要

A rhodium-catalyzed asymmetric 1,4-addition reaction has been applied to the synthesis of 2-aryl-4-piperidones.While other conventional nucleophiles fail,organozinc reagents have been successfully utilized for the construction of these useful compounds in very good yield and enantiomeric excess.