Development of Chiral Diaminophosphine Oxide Ligands and Application to Pd-Catalyzed Enantioselective Construction of Quaternary Carbons

摘要

We synthesized a novel P-chirogenic diaminophosphine oxide (4),which was applied to catalytic enantioselective construction of quaternary carbons using Pd-Catalyzed asymmetric allylic substitution with various beta-keto esters.Mechanistic studies indicated that two molecules of 8,witch is generated in situ by BSA-induced tautomerization of 4,coordinated to Pd metal in a monodentate fashion,resulting in the formation of the catalytically active Pd complex 9 (Pd:8 = 1:2).