Inotropes and vasopressors form the cornerstone for pharmacological support of the circulation. The principle aim of these drugs is to restore inadequate systemic and regional perfusion to physiological levels in conditions of circulatory failure. These drugs are increasingly used to augment the circulation in situations where the circulation is ostensibly normal, with the specific aim of increasing or improving regional perfusion. This strategy has been used for many years and has been directed at the prevention or amelioration of acute renal failure, hepatic insufficiency, and acute brain syndromes. Regarding the latter, inotropes and vasopressors have been used in the management of neurological conditions, such as traumatic brain injury and aneurysmal subarachnoid haemorrhage.
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