IDENTIFICATION OF PHARMACEUTICAL CRYSTALLIZATION PROCESSES

摘要

A key bottleneck in the production of Pharmaceuticals is in the formation of crystals from solution. The control of the crystal size distribution can be critically important for efficient downstream operations such as filtration and drying, and product effectiveness (e.g., bioavailability, tablet stability). This paper provides an overview of recent developments in the identification of pharmaceutical crystallization processes. This includes descriptions of recent activities in sensor technologies, model identification, experimental design, and robustness analysis of pharmaceutical crystallization processes.