Spatiotemporal Source Imaging of Brain Magnetic Fields Associated with Short-term Memory by Linear and Nonlinear Optimization Methods

摘要

In biomagnetic inverse problem, it is important to select optimal method, especially in the case of estimating internal electrical sources for higher functions with poor information about their source profile. In this study, internal sources of brain magnetic fields associated with short-term memory processes were estimated by (1) nonlinear parameter optimization method using multi dipole model, and (2) linear optimization method using L1 minimum norm estimation (L1-MNE) technique. Both methods showed internal sources in the inferior part of the occipital lobe, the supramarginal gyrus and the angular gyrus, and the inferior frontal gyrus. This result indicate the reliability and availability of these methods for brain magnetic data associated with higher brain function.