Prediction of Human Protein-protein interactome: Point

摘要

As the genes of the human genome become known, one of the challenges is to identify all the interactions of the human genes. Direct determination of all the interactions between the whole human genes is still difficult even with current large-scale protein interaction detection methods. Protein interactions are well-characterized for several organisms such as Saccharomyces cerevisiae due to the detection methods in proteomics technology. We proposed a method to predict human protein-protein interactions using the concept of homologous mapping by BLASTP from yeast to human. In a word, an interaction is inferred between two candidate proteins Hsl and Hs2 if two proteins Ystl and Yst2 are respectively homologous with Hsl and Hs2 and were previously described by DIP as interacting partners.