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The Effects of the Selective Atrial 5-HT4 Stimulation Before and After 6 Hours of Atrial Fibrillation

机译:在心房颤动前后选择性的心房5-HT4刺激的影响

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We investigated the effects of the selective 5-HT4 receptor agonist RS67333 on atrial effective refractory period (ERP), monophasic action potential (MAP), ERP/MAP ratio and time to sinus rhythm restoration (TSRR), before and following 6 hours of atrial fibrillation (AF). We studied 17 pigs, 7 RS67333-treated and 10 controls. ERP, MAP and ERP/MAP ratio were assessed at baseline, following RS67333 (in treated) or placebo (in controls) infusion and after 6 hours of AF. RS67333 shortened MAP, while ERP was not significantly increased. Following 6 hours of AF, no difference between groups was observed in ERP, MAP, ERP/MAP ratio and TSRR.
机译:我们研究了选择性5-HT4受体激动剂RS67333对心房有效耐火期(ERP),单一的动作潜力(MAP),ERP / MAP比和时间到窦性能恢复(TSRR)的影响,以前和之后进行过心房纤维化(AF)。我们研究了17只猪,7卢比,7 rs67333治疗和10个对照。在基线下评估ERP,地图和ERP / MAP比率,如RS67333(治疗)或安慰剂(对照组)输注和6小时后AF。 RS67333缩短地图,ERP没有显着增加。在6小时的AF后,在ERP,MAP,ERP / MAP比和TSRR中观察到组之间的差异。

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