The metabolic syndrome revisited

摘要

The Banting Memorial Lecture at the June Meeting of the American Diabetes Association is a highlight of the international medical and scientific life in the field of diabetes. It recognizes the scientific and medical achievements of a long-standing career. In 1988, Dr. Gerald Reaven gave the Banting Lecture at the ADA Meeting in New Orleans [1]. His title was ?he role of insulin resistance in human disease)). In his lecture, Dr. Reaven made three major points: (1) he drew the attention on a clustering of signs and symptoms making a Syndrome that he called ?yndrome X?. These signs and symptoms included: resistance to insulrn-stimulated glucose uptake, glucose intolerance, hyperinsulinemia, increased VLDL triglycerides, decreased HDL cholesterol and hypertension; (2) he suggested that, in this Syndrome, the common feature was insulin resistance and that the other components were secondary to the resistance to insulin; and (3) he concluded, rather provocatively, that resistance to insulin-stimulated glucose uptake may play a crucial role in determining who will and who will not develop coronary artery disease...?.