Pharmacokinetlc study of ropivacaine for labor analgesia with intermittent intrapartum administration and top-up expulsion dose

摘要

The aim of the study was to measure and analyzed the concentration of free ropivacaine in maternal plasma during labor with intermittent intrapartum administration of 0.2% ropivacaine. Our study showed a significant decrease of ropivacaine doses from 17.6 +- 0.49 mg to 13.6 +- 0.7 mg with no modification in comfort interval after each injection. Concentration of free ropivacaine was significantly higher after second and third epidural doses. The highest concentration was determined 25 min after expulsion. Conclusions: A small decrease in ropivacaine doses during progress of labor does not decrease the maternal plasma concentration. Top-up doses do not increase the expulsion concentration. The highest concentration of ropivacaine was recorded 25 min after top-up doses and constant decrease in postpartum study interval.