EVALUATION OF COLD TWO COMPARTMENT MINIMAL MODEL IN TYPE 2 DIABETES

摘要

Recent studies indicated that glucose effectiveness (S_G) is overestimated and insulin sensitivity (S_I) is underestimated with the one-compartment minimal model (1CMM) of glucose kinetics. To correct these errors, Cobelli et al (1999), incorporated a priori knowledge on glucose exchange kinetics using the individual Bayesian estimation to derive S_I and S_G with the 2CMM during standard IVGTT in healthy subjects. The present study evaluated 2CMM in subjects with type 2 diabetes during insulin-modified IVGTT and compared its performance with 1CMM, and with the glucose clamp as the gold reference. The 2CMM measured the same S_I and S_G as the 1CMM and underestimated S_I measured by the clamp. For its simplicity and popularity and to benefit from the data available in the literature 1CMM is preferred to 2CMM in type 2 diabetes.