Lack of Association between Chlamydia Pneumoniae Antibodies and Endothelial Function as Assessed by Flow-mediated Dilation

摘要

Chlamydia pneumoniae (C. pneumoniae), causing chronic infection may promote the development of atherosclerosis and reduce endothelial function. The aim of our study was to evaluate the association between elevated C. pneumoniae antibody titcrs and ischemic heart disease (IHD), and flow-mediated dilation (FMD). We found an association between IHD and high (> 256) IgA and IgG C. pneumoniae antibody liters (p=0.048, p=0.011, respectively). We found no difference in seroposi-tivity for C. pneumoniae antibodies in patients with IHD, compared to patients without IHD, regardless of gender and immunoglobulin class. There were no differences in FMD between patients with high and low IgA and IgG C. pneumoniae antibody titers. There were no differences in FMD between patients with seropositivity for IgA and IgG C. pneumoniae antibodies, respectively, and seroncgativc patients.