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INFERRING PHYLOGENETIC RELATIONSHIPS AVOIDING FORBIDDEN ROOTED TRIPLETS

机译:推断系统发育关系避免被禁止的根三胞胎

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To construct a phylogenetic tree or phylogenetic network for describing the evolutionary history of a set of species is a well-studied problem in computational biology. One previously proposed method to infer a phylogenetic tree/network for a large set of species is by merging a collection of known smaller phylogenetic trees on overlapping sets of species so that no (or as little as possible) branching information is lost. However, little work has been done so far on inferring a phylogenetic tree/network from a specified set of trees when in addition, certain evolutionary relationships among the species are known to be highly unlikely. In this paper, we consider the problem of constructing a phylogenetic tree/network which is consistent with all ofthe rooted triplets in a given set T and none of the rooted triplets in another given set F. Although NP-hard in the general case, we provide some efficient exact and approximation algorithms for a number of biologically meaningful variants of the problem.
机译:为了构建系统发育树或系统发育网络,用于描述一组物种的进化历史是在计算生物学中的一个良好研究的问题。先前提出的方法推断出大集物种的系统发育树/网络是通过在重叠的物种组上合并已知的较小的系统发育树的集合,以便不(或尽可能少)分支信息丢失。然而,到目前为止,在从一组指定的树上推断出系统发育树/网络时已经完成了一点工作,但是,已知物种中的某些进化关系是极不可能的。在本文中,我们考虑构建系统发育树/网络的问题,该系统与给定的集合T中的所有生根三联网一致,并且在另一个给定的集合F中没有生根三元组。尽管在一般情况下,但我们提供一些有效的精确和近似算法,有关问题的一些生物学上有意义的变体。

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