An electrical detector used for detecting the array-based electrical signal of DNA with nanoparticle probes has been fabricated and experimentally demonstrated. Compared with the traditional approach of optical signal based detection system' s, the proposed approach can significantly simplify the fabrication of integrated detection system for biochip applications. Furthermore, it can also produce a more integrated system with higher density. The details of fabrication steps and the procedures of attaching the target probe associated with gold nanoparticles onto the silicon-based fixture are presented in this paper. Experimental results show that a matched and unmatched DNA sample functionalised with gold nanoparticles can be distinguished. By using the silver enhancement and pre-hybridization method, the sensitivity of this array-based electrical signal detection system exceeds that of the traditional fluorescence detection system by two orders of magnitude.
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