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LIVER- AND LOBE-SELECTIVE GENE EXPRESSION FOLLOWING THE ADMINISTRATION OF NAKED PLASMID DNA TO THE LIVER SURFACE IN MICE

机译：肝脏和叶片选择性基因表达后，将裸体质粒DNA施用于小鼠肝脏表面

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摘要

The present study was undertaken to elucidate the liver- and lobe-selective delivery of gene following the administration of naked plasmid DNA (pDNA) to the liver surface in mice. This novel gene application is expected to be safe and effective method for the in vivo gene delivery.

机译：进行本研究以阐明在将裸体质粒DNA（PDNA）施用至小鼠肝脏表面后的基因的肝脏和叶片选择性递送。这种新的基因申请预计将是对体内基因递送的安全有效的方法。

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《Annual meeting of the Controlled Release Society》|2002年||共2页
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作者
R. Hirayama; S. Kawakami; K. Nishida; M. Nakashima; H. Sasaki; T. Sakaeda; J. Nakamura;
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原文格式 PDF
正文语种
中图分类制药化学工业;
关键词
DNA delivery; targeted delivery; transfection;

机译：DNA递送;靶向递送;转染;

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专利

1. Development of the liver- and lobe-selective nonviral gene transfer following the instillation of naked plasmid DNA using catheter on the liver surface in mice. [J] . Hirayama R, Kawakami S, Nishida K, Pharmaceutical research . 2003,第2期

机译：在小鼠肝表面上使用导管向裸质粒DNA滴注后，肝和叶选择性非病毒基因转移的发展。
2. Liver site-specific gene transfer following the administration of naked plasmid DNA to the liver surface in mice. [J] . Hirayama R, Nishida K, Fumoto S, Biological & pharmaceutical bulletin . 2004,第10期

机译：在小鼠体内将裸质粒DNA施用至肝脏表面后，肝部位特异性基因转移。
3. Liver- and Lobe-Specific Gene Transfer Following the Continuous Microinstillation of Plasmid DNA onto the Liver Surface in Mice: Effect of Instillation Speed [J] . Fumoto S, Tsuchimochi M, Nishi J, Biological & pharmaceutical bulletin . 2009,第7期

机译：将质粒DNA连续微滴注到小鼠肝表面后，肝和叶特异性基因转移：滴注速度的影响
4. LIVER- AND LOBE-SELECTIVE GENE EXPRESSION FOLLOWING THE ADMINISTRATION OF NAKED PLASMID DNA TO THE LIVER SURFACE IN MICE [C] . R. Hirayama, S. Kawakami, K. Nishida, Proceedings of the 29th Annual Meeting of the Controlled Release Society . 2002

机译：在小鼠体内将裸质粒DNA分配到肝表面后，肝和叶选择性基因的表达
5. Gene therapy for the treatment of hyperhomocysteinemia by naked DNA delivery. [D] . Lee, Mi-Young. 2007

机译：基因疗法通过裸DNA递送治疗高同型半胱氨酸血症。
6. Transgene expression and local tissue distribution of naked and polymer-condensed plasmid DNA after intradermal administration in mice [O] . R. Noelle Palumbo, Xiao Zhong, David Panus, -1

机译：小鼠皮内给药后赤裸和聚合物冷凝质粒DNA的转基因表达及局部组织分布
7. Liver Site-Specific Gene Transfer Following the Administration of Naked Plasmid DNA to the Liver Surface in Mice [O] . Hirayama, Ryu, Nishida, Koyo, Fumoto, Shintaro, 2004

机译：将裸质粒DNa给予小鼠肝脏表面后的肝脏位点特异性基因转移
8. THE MEASUREMENT OF LIVER CIRCULATION BY MEANS OF THE COLLOID DISAPPEARANCE RATE II. CHANGES IN LIVER- BLOOD FLOW PRODUCED BY FEEDING, EPINEPHRINE ADMINISTRATION, AND CHRONIC LYMPHATIC LEUKEMIA [R] . George F. Warner, Ernest L. Dobson, Muriel E. Johnston 1955

机译：用胶体消失率测量肝脏循环率II。喂养，EpINEpHRINE和慢性淋巴细胞白血病产生的肝脏血流量的变化

LIVER- AND LOBE-SELECTIVE GENE EXPRESSION FOLLOWING THE ADMINISTRATION OF NAKED PLASMID DNA TO THE LIVER SURFACE IN MICE

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