Evaluation of primary amines for peptoid synthesis and identification of by-products using LC-MS

摘要

Peptoids are oligomers of N-substituted glycine residues [1] and are structurally similar to alpha-amino peptides,stable to proteolysis,easy to synthesize,and most have potent biological activity.Recently,it has been shown that some peptoids also display antibacterial activity [2].Analysis of large petpoid libraries is a difficult and time-consuming task.Therefore,it is important to verify that primary amines used to build the library will be effectively incorporated at each synthetic step.