Biological activity,NMR and conformational analysis of peptide analogs of amino-terminal sequenceof RANTES

摘要

RANTES (regulation uon activation normal T-cell expressed and secreted) is a member of the CC-chemokine subfamily that acts as a chemoattractant for several kinds of leukocytes.Its biological activity results from binding to CCR5 receptors [1].It was shown that RANTES might play an important role in inhibiting of HIV replication of certain T-tropic strains in primary PMBC,and analogs of amino-terminal sequence with anti-HIV activity have been described [2].