Peptides or Peptide Analogs Against Gram-Negative Bacteria Having Kinked -Helical Conformations And Use Thereof

摘要

The present invention relates to a disconnected or bent spiral peptide, and a use thereof. More specifically, the present invention a gram negative bacterial membrane-permeable peptide having a structure of which alpha-spiral double-sided peptide consisting of hydrophobic amino acid and hydrophilic amino acid is bent, an antibacterial composition using the gram negative bacteria-specific membrane activities thereof, an antibacterial composition for combined injection, and a conjugate on which a drug is connected to the peptide, or an antibiotic including the same.