Computational docking and opioidmimetics:investigation of delta-opioid agonist and antagonist receptor interactions

摘要

Opioid receptors (delta,mu,kappa) and their endogenous ligands (enkephalins,endorphins,dynorphins and endomorphins) are located in the central nervous system and are eiminent for their efficacy in nociception.In addition a number of synthetic opioid therapeutics has been developed for immunosuppression [1],treating cocaine addiction [2],autism [3] and Tourette's syndrome [4].