Antimicrobial activity of SMAP-29 against clinically relevant anaerobic bacteria

摘要

SMAP-29 (RGLRRLGRKIAHGVKKYGPTVLRIIRIA-NH_2) is a 28-residue peptide first identified in sheep myeloid cells as a member of the cathelicidin family of antimicrobial peptides [1].This linear peptide undergoes a transition from random coil to alpha-helical conformation in the prescence of chemical agents (TFE,SDS_ mimicking a hydrophobic environment.