Solid-phase synthesis of peptide nucleic acids from N-tetrachlorophthaloyl protected monomers

摘要

The excellent binding properties of Peptide Nucleic Acids (PNAs) have attracted the interest of synthetic chemists and biologists.These oligonucleotides mimics are of interest as substances for potential therapeutic use.PNA hybridizes to comblementary DNA,RNA,or PNA oligomers,obeying the Watson-Crick base pairinmg rules,or forming triple helices via Hoogsteen base pairing.