Theoretical Predictions and Experimental Results for Non-Invasive Disease Treatment via High Intensity Focused Ultrasound: a Comparative Study

摘要

Center for Industrial and Medical Ultrasound, Applied Physics Laboratory, Univ. of Washington, Seattle, WA High-intensity focused ultrasound (HIFU) is becoming a widely accepted and "clean" modality to induce noninvasive coagulative necrosis of biological tissue for both cancer treatment and hemostasis. In this work, simulated results of HIFU treatment in turkey breast are analyzed and compared with equivalent in vitro experimental results. Attention is mainly focused on temperature and lesion evolutions; in particular, induced lesion boundaries and collateral damage to surrounding areas. The theoretical model (MEDUSA, MEDical UltraSound Algorithm), based on coupled acoustic full-wave solution and bioheat transfer equation, accounts for nonlinear sound propagation in inhomogeneous media, arbitrary frequency power law for acoustic attenuation, and temperature and lesion time histories. Our results show good agreement between the simulated lesions and the lesions created in fresh turkey breast in vitro.