Mycoplasmosis of swine or MPS, caused by Mycoplasma hyopneumoniae (MH) is a very important disease in the pig production industry. In Thailand it is also a serious economic problem. Since 1997-98 the PRDC surveillance showed that all twelve investigated farms were infected and about 73.5 % of sampling pig (147/200) were MH positive. Good hygiene management, vaccination and antibiotics are effective prevention and control measures of the disease. The susceptibility of microorganisms to antimicrobial agents may vary from place to place due to different field isolates, and how and what antibiotics and are used. An MIC study of some MH field isolates will provide useful data to select effective antibiotics for treatment of the disease and reduce the residue risk from non-effective ones. Finally, it will be a benefit to pig production and consumers. The objectives of this study were 1) to determine the minimum inhibitory concentrations (MICs) for nine antimicrobial agents against 27 MH fields isolate and 2) to study the trend of drug resistance in Thailand.
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