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Modeling Neural Spiking Activity in the Sub-Thalamic Nucleus of Parkinson's Patients and Healthy Primates

机译:帕金森患者亚丘脑核核心尖峰活性,健康制灵

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How neurons in humans encode information about the outside world and how this processing changes when the brain is diseased are central questions in neuroscience and medicine. Historically, microelectrode recordings of single-unit neuronal activity have been confined to animal preparations. Recently, it has become possible to obtain single-unit recordings in humans undergoing deep brain stimulation surgery. In this study, we recorded neuronal activity from the sub-thalamic nucleus (STN) of the basal ganglia of patients with Parkinson's disease (PD). In parallel, identical experiments were conducted on a healthy primate, providing a rare opportunity to analyze STN neuronal activity recorded in both the disease and healthy state during the same behavioral tasks. We developed point process models of STN neurons to capture neural spiking dynamics as a function of extrinsic stimuli and the neuron's own spiking history. Our models quantify, for the first time, pathological signatures in PD neural activity such as bursting, 10-30Hz oscillations, and loss of directional plurality, which may directly relate to motor disorders observed in PD patients such as bradykinesia, resting tremor, and rigidity.
机译:人类在人类中的神经元如何编码有关外界的信息以及当大脑患病时如何发生这种处理变化是神经科学和医学中的核心问题。从历史上看,单单元神经元活动的微电极记录已被限制在动物制剂中。最近,已经可以获得正在进行深脑刺激手术的人类中的单单元录制。在这项研究中,我们记录了帕金森病患者基底神经节(PD)的神经元核(STN)。同时,在健康灵长类动物中进行相同的实验,提供难得的机会,分析在相同的行为任务期间疾病和健康状态的STN神经元活动。我们开发了STN神经元的点流程模型,以捕获神经尖刺动力学作为外在刺激和神经元自身的尖刺历史的函数。我们的型号是第一次定量PD神经活动的病理签名,例如爆裂,10-30Hz振荡和定向多个损失,这可能与在PD患者(如Bradykinesia),休息震颤等PD患者中观察到的运动障碍。

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