Development of a Bioactive Inorganic/organic Composite for Bone Formation Active Drug Carrier

摘要

To develop a bioactive inorganic/organic composite matrix material, which could be applied in a proactive bone tissue regeneration therapy, a composite of ricalcium phosphate (TCP), and biodegradable poly-(L-lactide-co-glycolide-co-e-caprolactone) (PLGC), was designed and prepared with suitable biodegradable properties and good workability. Several kinds of TCP/PLGC composites with different composition ratio of the TCP and PLGC were prepared homogeneously by a heat-kneading method. The tensile strength of TCP/PLGC composite was changed with increasing of the TCP composition. And the maximum tensile strength and Young's modulus of TCP(75)/PLGC (the mass ratio of TCP and PLGC=75:25) was increased significantly in comparison with that of the others composites and pure PLGC sample sheet. In a soaking test with a phosphate-buffered saline, the mechanical strength of TCP/PLGC composites was gradually decreased with decreasing of the molecular weight of PLGC in the composites within one month. There is no difference in the tensile strength between the TCP/PLGC composite and the pure PLGC sample after one month soaking test. We are expecting that the TCP/PLGC composite with good bioactive property, suitable biodegradable properties and good workability could be applied in a proactive bone tissue regeneration therapy to realize simple, effective, and safe orthopedic substitutes and healing therapies.