Modelling and Intensification of Biocatalytic Production of Natural Compounds Performed in Hybrid Systems

摘要

In the past two decades, continuous growth of natural compounds production by biocatalytic conversion of different substrates can be observed. Biocatalytic production of many natural compounds is usually connected with a strong inhibition effect of the product. Therefore, strong academic and industrial interest has been devoted to the integration of reaction and separation steps into one operation unit, which can save raw materials, increase the productivity of the process and save capital and operational costs. In this paper, possibilities of biotechnological production of natural aroma 2-phenylethanol in different hybrid systems are discussed and compared with classical batch fermentation. Hybrid systems with in situ removal of the product from the fermentation broth are based on a combination of a bioreactor with membrane units like microfiltration, membrane based solvent extraction and a distillation unit. Two different configurations of hybrid systems were compared with the classical batch technology. The application of verified mathematical models of operational units (bioreactor, microfiltration module, extraction module, distillation unit) has shown, that the hybrid system, where the membrane module for extraction is immersed directly in the bioreactor can increase the annual productivity by approximately 1.7 times.