The Genetic Control of Ischemic Neuronal Cell Death

摘要

Apoptosis, Necrosis and Programmed Cell DeathApoptosis is the final event in programmed cell death, the mechanism by which neurons die during development. Whether neurons die by apoptosis or necrosis after cerebral ischemia remains controversial. Strictly speaking, apoptosis includes certain key morphologic features: condensation and cleavage of nuclear chro-matin, and the formation of budding cytoplasmic appendages known as apoptot-ic bodies. In addition, intracellular membranes and the plasma membrane remain intact until very late in apoptotic cell death, and there is little inflammation.