LC/MS METHOD TO DETERMINE PLASTICIZERS IN INDOOR DUST

摘要

The analysis of a broad range of plasticizers in indoor dust is necessary due to their widespread use, their ubiquitous occurrence in environmental media and their toxicological properties. Since commonly used GC methods are less suited to analyse compounds of low volatility a HPLC method has been developed. The method covers phthalates (up to C_(10)-alky-lated), adipates, an azelate and a trimellitate and is suitable for compounds of even higher molecular weight. A mass spectrometer with atmospheric pressure chemical ionisation (APCI) was used as a detector, which yields mass spectra of low and specific fragmentation. Typical performance characteristics of this analytical method are: recovery of 105% to 130 %, limits of determination from 150 μg/g down to 1 μg/g (based on a 50 mg dust sample, depending on blank value), repetitive RSD from 3 % to 16 %.