Fluorescent Probes and Labels for Biomedical Applications

摘要

Fluorescence probes and labels have become indispensable tools for clinical diagnostics, high-throughput screening, and other biomedical applications. We have developed several classes ofnew squaraine-based red and near-infrared (NIR) probes and labels (SETA and Square series),naphthalimide-based fluorescence lifetime dyes (SeTau series), and cyanine- and squaraine-basedquenchers (SQ series). This report discusses the spectral and photophysical properties of thesenew markers. In particular, the red and NIR dyes of the SETA and Square series are extremelybright, with photostabilities that are unmatched by any other dyes in the same spectral region.