Porcine Circovirus Type-2 (PCV2), Postweaning Multisystemic Wasting Syndrome (PMWS), Vaccines and the Immune System - What's Going On?

摘要

The immune system of the pig plays a key role in controlling infection by Porcine Circovirus Type-2 (PCV2), keeping it subclinical in most cases. However, a variable proportion of pigs in a farm may develop Postweaning Multisystemic "Wasting Syndrome(PMWS), a multi-factorial acquired immune deficiency syndrome. Unfortunately, the precise immunological mechanisms by which a pig gets a subclinical infection or develops PMWS are still poorly known. Curiously, PCV2 vaccines seem to be extremely efficacious for controlling the disease. The objective of this review is to summarise the current knowledge on PCV2 immunology and the immunological basis of PCV2 vaccination.