Passive repression of HIV-1 long terminal repeat controlled viral transcription by site-directed combinatorial design of artificial DNA-binding protein screened from combinatorial chemical libraries

摘要

The control of transcription of pre-specified genes by specific DNA-binding proteins is of great future importance due to therapeutic applications such as inhibition of cellular genes or entire viral genomes.In particular,HIV long terminal repeat (LTR) enhancer-binding proteins may suppress the transcription of the HIV provirus in infected cells.