Effect of polyL-lysine based polymer polypeptides on chemotaxis and phagocytosis of the unicellular tetrahymena pyriformis GL

摘要

Branched chain polymeric polypeptides with poly[L-lysine] core (poly[L-DL-Ala_m-X_i)]=XAK) have been used for a long time as macromolecular carriers of different drugs and peptide epitopes.Earlier studies have demonstrated,that charge and polarity of the amino acid constituents of the side-chains influence conformation in solution,phospholipd membrane interaction,biological properties like cytotoxicity and immunoreactivity and in vivo biodistribution.