Biosynthesis and biophysical studies of domains of sTE2P,a yeast G protein-coupled receptor

摘要

The yeast G protein coupled-receptor (Ste2p) is essential for the mating of MATa cells with their counterpart MATalpha cells.Mutation of Proline 256 located in the 6th transmembrane domain of this receptor constitutively activates it in the absence of the alpha-factor pheromone that is the normal agonist.