Synthesis of potent and enzymatically stable 4-~(18)F-benzoyl-NT(8-13) analogs for tumour diagnosis using PET

摘要

Neurotensin (NT),a tridecapeptide (pGlu-Leu-Tyr-Glu-Asn-Lys-Pro-Arg-Arg-Pro-Tyr-Ile-Leu-OH) was first isolated from bovine hypothalami.Following reports of abundant expression in many tumours,including Ewing's Sarcoma,non-endocrine pancreas carcinoma and meningioma the search for the development of a radiolabelled derivative of NT gained extensive and still growing interest.