Synthesis of ferrocene linkers for solid-phase synthesis of peptides

摘要

Peptides can be cleaved from the resin easier if they are attached to the resin through a selectively labile linker.The most common strategies used to date for the rleease of amides from insoluble supports are:(a) cleavage of a benzylic C-N bond of resin-bound N-alkyl-N-benzyl amides,(b) nucleophilic cleavage of resin bound acylating agents with amines and (c) acylation/debenzylation of resin-bound N,N-dibenzylamines.