Conformational studies of cyclotetrapeptides Xaa-Ala_2 by NMR,CD and molecular modeling

摘要

Small cyclopeptides are attractive molecular scaffoldings with reasonable rigidity and can be used as molecular templates for studies involving molecular recognition.Indeed,macrocyclic peptides have been investigated as probes to study molecular recognition by biomolecules,as well as ligands for metal ions.Nature also utilizes the peptide backbone to design ionophores,toxins and antibiotics,such as tentoxin,AM toxin,Gramicidin S and the depsipeptide,Valinomycin.