Synthetic approach to study the effects of beta-turn residues on the structure and folding of bovine pancreatic trypsin inhibitor (BPTI)

摘要

Previous work from our laboratory has established a system for accessing partially folded conformational ensembles of bovine pancreatic trypsin inhibitor (BPTI),based on the replacement of Cys5,30,51,and 55 by alpha-amino-n-butyric acid (Abu),while retaining the disulfide between Cys 14 and 38.