Mechanisms of liposome destabilization by amphipathic peptides, permanent and transient structures of the supramolecular complexes.

摘要

Amphipathic peptides correspond to a wide variety of natural compounds implicated in different biological functions like lipid transport, hormones, signaling, surfactants and toxins. Amphipathy, i.e. spatial seggregation of the poalr and apolar residues leading to high hydrophobic mommentscan result from sequence, primary amphipaths, look to block co-polymers. or for secondary amphipaths resulted from the adequate periodicity of both types of residues when folding, i.e. 2 or 3.6 periodicity according to folding into beta-sheets or alpha-helices.